I suppose Microsoft’s Vista is one example of a major project gone astray. You can get some interesting insight from one of the Microsoft folks here. Looks like programmer productivity at Microsoft is not all that it could be.
Microsoft is not alone. Airbus had a massive overrun as well. Over $6 billion due, in part, to project management issues.
Lots of other issues which allowed Boeing to leapfrog Airbus. Airbus had multiple and incompatible versions of their CAD app. Boeing enforced a single standard. Airbus struggled with all sorts of incompatible applications and data. Boeing used a suite of related apps from one vendor.
You can read the story here. Not all big projects go thud.